Production fermenters are available in Pilot version from 100 to 1000 litres and in Industrial version with volumes of up to 25 000 litres.
Production Fermenter
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- The straightforward concept in design and construction results in a user-friendly and sturdy high-tech plant. The central inlet/outlets for steam, water, air and waste water, minimize installation time and work.
- The flexible installation of Bioengineering probes and accessories for media addition, aeration, sampling, harvest, perfusion, load destruction, CIP, etc. is guaranteed with the standardized ports.
- The modular design in combination with the variety of proven accessories enable the performance of biotechnological processes with enzymes, microorganisms, fungi, algae, plant or animal cells.
- Our equipment fulfils the required national guidelines and cGMP/FDA-regulations (including IQ and OQ documentation on request).
- The stirrer unit is driven by a belt, thus reducing the fermenter height, separating the vessel from the motor, and optimizing the bearing of the free-swinging shaft. The shaft is removed form the tope and the bearing with the seals is easily disassembled from the bottom.
- The fermenter is aerated through the Bioengineering Autosterile filter. Without any complicated peripheral constructions, this filter is in-situ sterilizable together with the fermenter.
- The power supply and the measurement and control units in the 19" measurement cabinet are separated from the fermenter. The Bioengineering IFM controllers combine state-of-the-art digital technology with a modular set-up.
- Each measurement or control loop has its own separate module, thus enabling easy maintenance of single units or the adaptation of the fermenter measurement and controls according to actual requirements. The BioLogics or BioVisual software covers all data logging and visualization requirements. Other software systems are available on request.
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Standard |
Optional |
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Vessel |
Stainless steel 316 L
grain 240 |
Special alloys
mirror polished |
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Heating circuit |
Closed circuit, galvanized steel, heat exchanger for steam |
Stainless steel 316 L, electrical heater, heat exchanger for cooling circuits |
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Agitation |
Bottom drive by belt,
double mechanical seal |
Top drive,
Magnetic coupling |
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Mechanical seal |
Silicium carbide,
glycerine lubricated |
Steam condensate lubricated |
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Stirrer |
Blade stirrers, baffles |
Airlift, draught tube |
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Inlet air |
Autosterile filter, ceramic filter |
Separate filter, double filters,
absolute filter, gas mixing station |
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Aeration |
Submerse aeration |
Surface aeration, bubble-free aeration |
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Ports |
Standardized lid and side ports |
Flexible location and number, special ports |
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Viewing glasses |
Longitudinal and lid viewing
glass with illumination |
Flexible location and number |
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Exhaust air |
Ceramic filter |
Absolute filter, reflux cooler,
foam destruction, incinerator |
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Inoculation |
Inoculation port |
Fixed piping, transfer concepts |
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Sampling |
Manual sampling valve |
Pneumatic valve, contained sampling valve, valve with steel bellow, cell-free sampling system |
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Harvest |
Manual harvest valve with steel bellows |
Pneumatic harvest valve, fixed piping, transfer concept |
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Media addition |
Needle connection through lid |
Dosage valve, coupling, fixed piping, transfer concepts |
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Sterilization |
Manual sterilization of
Autosterile filter and exhaust air valve |
Automatic sterilization of autosterile filter and exhaust air valve |